Abstract
Obesity is a condition of imbalance in the number of calories entered by the number of calories where the excess is heaped up as body fat. Obesity followed by an increase in fat metabolism will cause Reactive Oxygen Species (ROS) production to increase. This condition causes oxidative stress. Indicators of oxidative stress can be observed from plasma levels of Malondialdehyde (MDA). This study aims to determine the risk factors for oxidative stress in obese women.
 The results of this study indicate that high fat intake (> 60 g / day) is at risk of increasing MDA-P levels twice. Low fiber consumption (<30 gr / day) gives the risk of an increase in MDA-P levels of 2.09 times. Poor physical activity is a risk factor for MDA-P increase of 1.15 times. High cholesterol (> 200mg / l) and LDL (> 130 mg / l) and low HDL (≤45mg / dl) levels are at risk of increasing MDA-P levels by 1.02 times (cholesterol), 1.13 (LDL) ) and 1.12 (HDL).
 Based on this study it can be concluded that high fat intake, low fiber intake, low physical activity, high cholesterol and HDL levels and low HDL levels are risk factors for oxidative stress.
Highlights
Obesity is a condition of imbalance in the number of calories entered by the number of calories where the excess is heaped up as body fat
The results of this study indicate that high fat intake (> 60 g / day) is at risk of increasing malondialdehyde plasma (MDA-P) levels twice
Based on this study it can be concluded that high fat intake, low fiber intake, low physical activity, high cholesterol and HDL levels and low HDL levels are risk factors for oxidative stress
Summary
Kata kunci: obesitas, stres oksidatif, MDA-P, asupan gizi, aktifitas fisik, profil lipid. Kadar kolesterol dan trigliserida yang tinggi di dalam darah dapat menjadi faktor resiko terjadinya aterosklerosis dan penyakit jantung [3]. Berdasarkan latar belakang tersebut, perlu dilakukan penelitian untuk mengetahui faktor risiko terjadinya stres oksidatif pada wanita obesitas. Subjek penelitian adalah pegawai wanita obesitas di lingkungan Dinas Kesehatan Kota Yogyakarta yang memenuhi kriteria inklusi dan eksklusi penelitian. Analisis data dilakukan dengan uji Chi Square untuk melihat hubungan antara variabel dependen dan variabel independen serta uji Odds Ratio untuk mengetahui faktor resiko yang berhubungan dengan kadar MDA-P sebagai indikator terjadinya stres oksidatif. Variabel independen yang diamati antara lain asupan gizi (protein, lemak, karbohidrat dan serat), aktifitas fisik dan profil lipid (kolesterol, trigliserida, LDL dan HDL). Jika dilihat dari penggunaan alat kontrasepsi, sebagian besar subjek penelitian menggunakan alat kontrasepsi non hormonal (53,03%), yaitu IUD, steril dan sistem kalender.
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