Analysis of risk factors of cerebral infarction in young adults and its correlation with TOAST types

Abstract

Objective To explore the risk factors of youth cerebral infarction and its correlation with clinical TOAST types. Methods 82 young patients with acute cerebral infarction(aged from 18 to 45 years old) were selected.The risk factors for youth cerebral infarction patients, and the proportion of TOAST subtype and related risk factors were analyzed. Results Risk factors for youth cerebral infarction were as follows: hyperlipidemia (χ2=48.703, P<0.05), hypertension (χ2=40.829, P<0.05), carotid sclerosis (χ2=46.217, P<0.05), hyperhomocysteinemia (χ2=40.255, P<0.05), smoking history (χ2=7.853, P<0.05), diabetes (χ2=18.256, P<0.05) and family history (χ2=5.944, P<0.05), heart disease (χ2=5.754, P<0.05). The proportion of their TOAST subtypes were as following: small artery occlusion lacunar(SAD)(39.0%), large artery atherosclerosis(LAA)(24.4%), stroke of other undetemined etiology(SUE)(17.0%), and acute stroke of other detemined etiology(SOE)(12.2%), cardioembolism(CE) type(7.3%). Major risk factors for LAA subtype included hyperlipidemia, hypertension and carotid atherosclerosis; Major risk factor for SUE subtype was hyperhomocysteinemia; Major risk factors for SOE included hypertension, diabetes.Major risk factor for CE subtype was heart disease. Conclusion The highest proportion of TOAST types in youth cerebral infarction group is small artery occlusion lacunar.Major risk factors for this group of youth cerebral infarction are as follows: hypertension, carotid atherosclerosis, heart disease, diabetes, hyperhomocysteinemia, obesity, smoking and family history, and these risk factors should be actively intervened. Key words: Cerebral infarction; Youth; TOAST types; Risk factors