Abstract
Herbs and their combinations due to the wide range of biologically active substances can influence on various links of the pathogenetic mechanism of development of diabetes mellitus and its complications. One of such combinations is an antidiabetic herbal mixture with established hypoglycemic, hypolipidemic, antioxidant, hepatoprotective, pancreatoprotective activity in previous pharmacological study in vivo that including an inulin-containing component – Taraxacum officinale L. roots. Thus, the aim of this study was to determine the quantitative content of inulin and fructans in Taraxacum officinale L. Quantity content of inulin was determined by the difference between fructose as a product of enzymatic hydrolysis and D-fructose, a constituent of sucrose and free D-fructose, taking into account the empirical factor for the conversion of D-fructose from inulin. Carbohydrates used in the calculation of inulin were separated by gas chromatography-mass spectrometry after conversion into volatile derivatives as aldononitrile acetate. According to the results, Taraxacum officinale L. roots contain 436.29 mg/g of inulin. Total content of fructans was determined by spectrophotometric analysis as a product of acid hydrolysis of 5-(hydroxymethyl)furfural. The results show that Taraxacum officinale L. roots contain 39.49% of fructans. The obtained results are evidence that this plant component should be included in the herbal antidiabetic mixture, because due to the presence of fructans and inulin causes hypoglycemic, hypolipidemic and detoxification activity.
Highlights
Diabetes mellitus is one of World Health Organization priorities matters, which requires immediate solutions, as the epidemiological situation is alarming – the number of patients is growing rapidly each year, leading to increased disability and mortality due to the development of macro- and microangiopathies (Harding et al 2019; American Diabetes Association 2021)
Modern pharmacotherapy is increasingly taking into account the centuries-old experience of folk medicine using phytomedicines as monotherapy and in combination with synthetic drugs
Particular attention deserve the combinations of different medicinal plants, because such herbal mixtures will have more biologically active substances that will influence on the all links of the pathogenetic mechanism of development of diabetes mellitus and its complications (Savych et al 2020a, b, c, d, e, f; Savych et al 2021a, b, c, d, e, f, g)
Summary
Diabetes mellitus is one of World Health Organization priorities matters, which requires immediate solutions, as the epidemiological situation is alarming – the number of patients is growing rapidly each year, leading to increased disability and mortality due to the development of macro- and microangiopathies (Harding et al 2019; American Diabetes Association 2021). Savych A et al.: Analysis of inulin and fructans in Taraxacum officinale L. roots. Modern pharmacotherapy is increasingly taking into account the centuries-old experience of folk medicine using phytomedicines as monotherapy and in combination with synthetic drugs. It became quite justified, after all as phytotherapy has a number of advantages over traditional therapy with using synthetic agents, namely, it is low-toxic, has a mild pharmacological effect and possibility to be used for long periods of time without significant side effects and is well combined with synthetic drugs (Gothai et al 2016; Governa et al 2018). Particular attention deserve the combinations of different medicinal plants, because such herbal mixtures will have more biologically active substances that will influence on the all links of the pathogenetic mechanism of development of diabetes mellitus and its complications (Savych et al 2020a, b, c, d, e, f; Savych et al 2021a, b, c, d, e, f, g)
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