Abstract
The herbal mixtures due to the wide range of biologically active substances can influence on various links of the pathogenetic mechanism of development of diabetes mellitus and its complications. The carbohydrates, especially inulin, deserve the particular attention through their hypoglycemic, hypolipidemic, anticholesterolemic and detoxifying activities. The aim of the study was to investigate the content of inulin in the herbal mixtures No. 3, No. 4, No. 7, No. 13 and No. 19, which are used in folk medicine for the prevention and treatment of diabetes mellitus type 2 in Ukraine. The quantity content of inulin was defined by the difference between fructose as a product of enzymatic hydrolysis and fructose, a constituent of sucrose and free fructose, taking into account the empirical factor for the conversion of fructose from inulin. The carbohydrates were separated by gas chromatography-mass spectrometry after conversion into volatile derivatives as aldononitrile acetate. According to the results, the herbal mixture No. 3 contains 458.97 mg/g of inulin, the herbal mixture No. 4 – 99.21 mg/g, the herbal mixture No. 7 – 139.93 mg/g, the herbal mixture No. 13 – 203.84 mg/g, the herbal mixture No. 19 – 359.65 mg/g. The availability of inulin and its high content in the investigated herbal mixtures due to the presence of inulin-containing medicinal plants, such as Cichorium intubus roots (mixtures No. 3 and No. 13), Taraxacum officinale roots (mixtures No. 3, No. 7 and No. 19), Arctium lappa roots (mixture No. 4), Inula helenium rhizome with roots (mixture No. 7).
Highlights
Diabetes mellitus is a major problem of World Health Organization, as the epidemiological situation is becoming alarming – the number of patients with diabetes is increasing every year, and with it the number of deaths and disabilities through the development of micro- and macroangiopathies (Harding et al 2019; American Diabetes Association 2020)
Particular attention deserve the combinations of different medicinal plants, because such herbal mixtures will have more biologically active substances that will influence on the all links of the pathogenetic mechanism of development of diabetes mellitus and its complications
Active substances of plant origin have a wide range of pharmacological action and a variety of mechanisms of influencing on the development of diabetes and diabetic angiopathies (Oh and Jun 2014; Kooti et al 2016; Skyler et al 2017; Savych et al 2019)
Summary
Diabetes mellitus is a major problem of World Health Organization, as the epidemiological situation is becoming alarming – the number of patients with diabetes is increasing every year, and with it the number of deaths and disabilities through the development of micro- and macroangiopathies (Harding et al 2019; American Diabetes Association 2020). Active substances of plant origin have a wide range of pharmacological action and a variety of mechanisms of influencing on the development of diabetes (the pathogenesis of which involves the development of insulin resistance; relative insulin deficiency, which becomes the cause of decrease the secretory activity of β-cells of the pancreatic gland) and diabetic angiopathies (the pathogenesis of which are activation of lipid peroxidation, inactivation of antioxidant protection system and development of oxidative stress) (Oh and Jun 2014; Kooti et al 2016; Skyler et al 2017; Savych et al 2019) For this purpose, it is advisable to study the phytochemical compounds, namely the inulin from group of carbohydrates in the investigated herbal mixtures, which are used in folk medicine for the prevention and treatment of diabetes mellitus type 2 in Ukraine (Tovstuha 2010). Inulin has hypoglycemic activity due to its ability to increase glucagon-like peptide-1(GLP-1), which increases the secretion of insulin, inhibits the secretion of glucagon and somatostatin, causes the proliferation and neogenesis of β-cells and increases the response of β-cells to glucose (Kietsiriroje et al 2018; Paternoster and Falasca 2018)
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