Analysis of intrinsic risk factors of the postoperative infection in patients with recurrent intracranial neoplasm

Abstract

Objective To clarify the intrinsic risk factors contributing to postoperative infection in patients with recurrent brain tumor. Methods The clinical characteristics of patients with recurrent intracranial neoplasm were collected and analysed retrospectively. The intrinsic risk factors for postoperative intracranial infection were evaluated by χ2 test. The multivariate Logistic regression analysis was employed to select the independent variables associated with postoperative intracranial infection. Results Tumor size, long-term bed, preoperative extracranial infection, diabetes, malnutrition, anemia, hypoproteinemia, organ dysfunction and autoimmune disease had significant effect on postoperative infection, which revealed by the univariate analysis. Multivariate analysis showed that tumor size, preoperative extracranial infection and diabetes contributed to postoperative intracranial infection as independent risk factors. Conclusion Tumor size (diameter > 5 cm), preoperative extracranial infection and diabetes are potential predictors of high risk for postoperative intracranial infection. Efforts should be made to control the factors mentioned above in order to minimize the probability of postoperative infection in patients with recurrent intracranial neoplasm. DOI:10.3969/j.issn.1672-6731.2011.04.016