Abstract
The aim: to study the features of daily profile and circadian rhythm of blood pressure (BP) in groups of patients with type 1 diabetes mellitus (T1DM), depending on glycemic control. Materials and methods: 63 patients with T1DM, age: 18-45 years without hypertension were examined. Patients were divided into groups: Group 1 — HbA1c≤7.0% (n=21), Group 2 — HbA1c>7.0% (n=42). 10 sex- and agematched healthy controls were included. Results: Patients with T1DM had a significantly higher pulsatile blood pressure (PBP) per night, higher daily systolic blood pressure (SBP) variability, compared with healthy controls, and significantly higher daily SBP area index (SPAI24), daily SBP time index (SPTI24), daily diastolic blood pressure (DBP) area index (DPAI24), daily DBP time index (DPTI24). The double product (DP) was higher in patients with T1DM in the daytime and within 24 hours compared to control (p=0.002) and (p=0.001) respectively. Pathological profiles of daily blood pressure were found. In group 1, according to the dipping in SBP 28.57% of patients were non-dippers, 4.76% were extreme dippers. In group 2, the non-dipper profile had 33.33%, the reverse dipper had 2.38%, and extreme dipper had 11.90% of patients. According to the dipping in DBP: in group 1 33.33% were non-dippers, and 9.53% were extreme dippers. In group 2 non-dippers — 19.04%, extreme dippers — 2.38%, extreme dippers — 38.10%. HbA1c directly correlates with: (DPAI24) (ρ=0,301; р=0,014), DPAI night (ρ=0,292; р=0,010), DPTI24 (ρ=0.292; p=0.012), DPTI night (ρ=0.268; p=0.018). Conclusions. The daily blood pressure profile in patients with T1DM without arterial hypertension is characterized by insufficient decrease in BP at night, an increase in the average daily DBP, PBP, as well as DPAI24, DPTI24, DP and the variability of the average daily SBP. Poor glucose control led to led to an increase in hemodynamic load. It is the risk factor cardiovascular complications in patients with T1DM.
Highlights
Patients were divided into groups
The daily blood pressure profile in patients with type 1 diabetes mellitus (T1DM) without arterial hypertension is characterized by insufficient decrease in BP
Poor glucose control led to led to an increase in hemodynamic load
Summary
Мошенець профілю артеріального тиску в пацієнтів із цукровим діабетом 1-го типу залежно від перебігу захворювання. Мета — дослідити особливості добового профілю та циркадіанного ритму артеріального тиску (АТ) у групах хворих на цукровий діабет 1-го типу (ЦД1) залежно від глікемічного контролю. Добовий профіль АТ у хворих на ЦД1 без АГ характеризується недостатнім зниженням АТ уночі, збільшенням середньодобових ДАТ, ПАТ, ІПДАТ доб., ІЧДАТ доб., ІПД доб. Прогностичну значущість відносно серцево-судинних ускладнень мають не лише абсолютні показники систолічного (САТ) і діастолічного (ДАТ) артеріального тиску. Проведення добового моніторингу артеріального тиску (ДМАТ) у пацієнтів із ЦД1 дозволяє детально вивчати циркадіанні характеристики добового профілю АТ залежно від перебігу захворювання та визначати найбільш значущі показники прогнозування розвитку діабетичної нефропатії. Мета роботи — дослідити особливості добового профілю та циркадіанного ритму артеріального тиску у хворих на цукровий діабет 1-го типу залежно від глікемічного контролю
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
