Analysis of correlation between fractional amplitude of frequency fluctuation for resting-state fMRI and Go/Nogo task performance in undergraduate

Abstract

Objective To investigate the correlation of spontaneous brain activity and Go/Nogo task performance with fractional amplitude of low-frequency fluctuation (fALFF)of the resting-state fMRI, and explore the functional basis of response inhibition. Methods Twenty-four college students were experienced resting-sate fMRI scans and Go/Nogo task and blood oxygenation level dependent (BOLD) signal and task behavioral performance were acquired to calculate the fractional amplitude of low-frequency fluctuation (fALFF)and intra-individual coefficient of variation(ICV). Pearson's correlation analysis between the fALFF values and the ICV was performed in a voxel-wise manner to get the significant fALFF-ICV correlation map(corrected, P<0.05). Results Significant negative fALFF-ICV correlations were observed in right gyrus rectus(BA11, r=-0.66), right superior frontal gyrus(BA10, r=-0.82), left mediate frontal(BA10, r=-0.80), left inferior frontal gyrus(BA45, r=-0.78), right inferior parietal lobule(BA2, r=-0.78), left supplementary motor area(BA6, r=-0.70) and right cerebellum(r=-0.63) .Significant positive fALFF-ICV correlations were observed in bilateral cuneus gyrus(BA18/19, r=0.68), left middle occipital cortex(BA19, r=0.73), left inferior occipital cortex(BA19, r=0.76) and bilateral lingual gyrus(BA17, r=0.77). Conclusion Close correlations between resting-state brain activities and Go/Nogo task performance are observed in the frontal cortex, supplementary motor area, posterior occipital lobe, cerebellum and some DMN regions.It is indicated that prefrontal cortex may have important influence on the efficiency of response inhibition, meanwhile, the default mode network may have possible influence on the efficiency of task performance. Key words: Resting-state functional magnetic resonance; Fractional amplitude of low frequency fluctuation; Go/Nogo task; Intra-individual coefficient of variation; Response inhibition