The characteristics of resting-state brain function in patients with bipolar depression

Abstract

Objective To explore the characteristics of spontaneous neural activity of resting-state brain function in patients with bipolar depressionby using fractional amplitude of low frequency fluctuation (fALFF). Methods Resting-state functional magnetic resonance data in twenty-six patients with bipolar depression and twenty-six healthy controls was finally adopted by processing. After preprocessing functional imaging data, the fractional amplitude of low frequency fluctuation (fALFF) values was used to estimate the spontaneous neural activities of different brain regions. Finally, a two sample t-test was performed on the mean fALFF values of the different brain regions between bipolar depression group and the healthy control group. A P-value of 13, P<0.001) . Results The patients with bipolar depression demonstrated significantly lower fALFF values in the right posterior cingulate gyrus (t=-4.49), the left inferior parietal lobules(t=-4.29), the left precuneus(t=-5.05), and the right superior frontal gyrus(t=-5.04, t=-3.86) relative to the control group. In addition, their fALFF values in the left middle occipital gyrus(t=3.92) and the bilateral lingual gyrus(t=5.04) were significantly higher (P<0.01) . Conclusions Patients with bipolar depression manifest abnormal spontaneous neural activities in the default mode network and the visual network-related brain regions. Key words: Bipolar disorder; Magnetic resonance imaging; Fractional amplitude of low frequency fluctuation; Resting-state