Analysis of clinical distribution and drug resistance of pseudomonas aeruginosa in the Sixth Hospital of Ningbo

Abstract

Objective To investigate the drug resistance of pseudomonas aeruginosa changes in the Sixth Hospital of Ningbo, Zhejiang province, in order to provide a basis for clinical rational use of antimicrobial drugs. Methods The clinical distribution and drug resistance to commonly used antimicrobial agents in 1970 strains of pseudomonas aeruginosa from the Sixth Hospital of Ningbo in 2014-2016 were retrospectively analyzed.The data were statistically analyzed using WHONET 5.6 software, excel software, SPSS17.0 software. Results Clinical specimens isolated 15 963 strains of pathogenic bacteria, including 1 970 strains pseudomonas aeruginosa, accounted for 12.34%.The detection rate of multi-drug resistance pseudomonas aeruginosa(MDRPA) reduced year by year, the detection rate in 2014 was 60.95%, which in 2015 was 58.00%, which in 2016 was 45.58%.Pseudomonas aeruginosa was mainly isolated from sputum(67.16%), followed by wound secretion(23.05%). The detection rate of pseudomonas aeruginosa in ICU and geriatric department was higher, accounted for 20.25% and 25.28% respectively.The resistance of pseudomonas aeruginosa to many kinds of antimicrobial agents was increased from 2014 to 2016, the resistance rates to cefoperazone/ sulbactam were>30% in 3 years, the resistance rate to imipenem was higher than meropenem.The drug resistance of pseudomonas aeruginosa isolated from sputum in ICU was higher than that in geriatric department(all P<0.05). Conclusion Pseudomonas aeruginosa nosocomial infection in the Sixth Hospital of Ningbo is severe, the infection rate and drug resistance monitoring should be strengthened, in order to reduce the infection rate and drug resistance. Key words: Pseudomonas aeruginosa; Drug resistance, bacterial; Infection; Anti-bacterial agents; Small-area analysis