Abstract
A method based on zwitterionic hydrophilic interaction liquid chromatography (ZIC-HILIC) and mass spectrometry (MS) is presented for determination of mono-, di-, triethanolamine (EA, DEA, TEA), iso-, N-propanolamine (IPA, NPA), diisopropyl ethanol amine (DIPEA), 2-diethylethanol amine (DEEA), diisopropanol amine (DIPA), dimethylethanol amine (DMEA), N-methyldiethanol amine (MDEA) in aqueous solutions. Linear calibration graphs (0.04-3.0 µg mL-1, n=9) were obtained with correlation coefficients in the range of >0.96 using N-tripropyl amine (NTPN) as internal standard and >0.99 using NPA as internal standard. The instrumental detection limit was below 44 fmol. Chromatographic separation of the 10 studied alkanolamines was achieved. Injection volumes up to 3 µL was enabled using on-column. The optimal solvent composition was found to be 100 % water with 0.01 % acid at pH<4. Sample solution concentrations of 1.0 µg mL-1 could be injected on the column with sustained chromatography.
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