Analysis of 9260 cases of cervical cytology liquid-based thin-layer analysis

Abstract

Objective To explore the role of thinprep cytology test(TCT)and HPV-DNA hybrid capture detection played in the screening of cervical lesions.Methods Do TCT examination on 9260 outpatients and do HPVDNA hybrid capture detection on 840 cases therein,836 positive cases continued to have biopsy by colposcope,conformed to the gold standard of histopathology and contrast with cytology in the meantime.Results 8374 cases were negative in the TCT examination;836 cases were cytological abnormal.Cytology-positive rate was 9.03％,ASC-US 398 were 4.29％,LSIL 239 were 2.58％,HSIL 179 are 1.93％,SGUS 9 are 0.097％,SCC 11 are 0.12％.The group of 30 ～40 ranked the highest in cytological positive,it's 43.66％,the second highest was the group of 40 to 50,it's 27.39％.The results of other groups were as follow:＜ 30 is 2.85％,50 ～ 60 is 5.14％,＞ 61 is 0.96％ The difference of them was significant ( P ＜ 0.01 ).HPV infection rate was 27.98％ (235/840).In ASC-US,the detectable rate of CIN in the HPV-positive group was 81.58％ (31/38),the HPV-negative group was 8.98％ ( 15/167),there was significant differene between the two methods(P ＜ 0.01 ).In LSIL,the detectable rate of CIN in the HPV-positive group was 95.45％ (21/22).In HSIL,the detectable rate of CIN in the HPV-positive group was 100％ (16/16).The infection rate in different age group is different,the difference was significant ( x2 =25.2 P ＜ 0.01 ) ; 836positive cases had biopsy by colposcope,507 cases were diagnosed to be CIN,the detectable rate was 60.65％ (507/836).To organize pathology as control,the diagnose accordance rate of cytology and pathology of LSIL and HSIL and SCC were 50.46％,82.12％,100％ (P ＜0.01 ).Took their accordance rate into comparison,the differene was significant.Conclusion Cervical lesion was collected in sex activity period,the peak was 31-40 years.TCT is propitious to screen cervical cancer and precancerous lesion,combined with HPV-DNA hybrid capture detection,colposcopy and pathology,can improve the diagnostic accuracy and the detective rate of CIN and cervical cancer. Key words: Thinprep cytology test ( TCT ) ; Cervical lesions; Human papillomavirus (HPV)