Abstract
Objective To investigate the pharmacoepidemiologic features of drug-induced hypersensitivity syndrome(DHS)and improve the recognition of its particularity. Methods The clinical data of 28 patients with DHS were retrospectively analyzed and summarized. Results Of 28 DHS patients,the suspected drugs were allopurinol in 17 cases,anti-epileptic drugs in 4 cases,antiuberculotic drugs in 3 cases and non-steroidal antiinflammatory drugs in 4 cases.The earliest symptoms of DHS were skin rash(89.3%) and fever(85.7%),secondly liver function damaged(75.0%),which may be accompanied by mucosa,eye,genital damage(53.6%),eosinophilia(32.1%),renal impairment(17.9%),even multiple organ failure and death. Conclusion DHSshould be on the alert when rash,repeated fever and visceral lesion occurred in a patient,without good therapeutic efficacy through ordinary antianaphylaxis and anti-infective therapy,as well as with the above medication history. Key words: Drug-induced hypersensitivity syndrome; Allopurinol; Antiuberculotic drugs; Anti-epileptic drugs; Non-steroidal anti-inflammatory drugs
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