Analogs of somatostatin. Part A. Chemistry and in vitro results.

Abstract

Recently, we reported on the synthesis of Somatostatin by a classical fragment approach (Immer et al., 1974). This method avoids the problematic cyclization of dihydrosomatostatin (Rivier, J.E.F., 1974, Fujii, N. and Yajima, H., 1975) and leads to the desired product in high yield. Essentially, the same synthetic scheme was employed for the preparation of three groups of somatostatin analogs discussed here: 1) Shortened Analogs of Somatostatin. 2) Elongated Analogs of Somatostatin 3) Retroenantio Analogs of Somatostatin Derivatives.