Abstract
Leucas hyssopifolia Benth. (Lamiaceae) is an annual herb found throughout the India as a weed in cultivated fields, wastelands and roadsides. The aim of the present study was to investigate the presence of phytochemicals and to screen pharmacological activity of Leucas hyssopifolia. The ethyl acetate fraction of the L. hyssopifolia roots was prepared and varying doses (25, 50 & 75 mg/kg, i.p.) of ethyl acetate fraction were given 30 minutes prior to the induction of abdominal constrictions and determination of the mean reaction time in hot plate maintained at 55.0 ± 0.50°C. The ethyl acetate fraction exhibited significant and dose dependent antinociceptive property against acetic acid induced abdominal constrictions in mice. The percentage reduction in numbers of writhes observed with ethyl acetate fraction was 56.9, 75.3 and 80.0%, respectively with 25, 50 and 75 mg/kg doses (p<0.05). In the hot plate, all the doses of ethyl acetate fraction produced a time dependent increase in mean reaction time and a significant effect was observed after 30 min of administration (p<0.05).
Published Version
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