Abstract
A minature bubble oxygenator with integral heat exchange has been developed for high flow, normothermic, total cardiopulmonary bypass in rats: priming volume, 25 ml; flow rate, up to 260 ml/kg/min; survival after a 2-hr total bypass. It is thus possible to use rats for cardiothoracic surgical research and to make use of the many advantages of a standardized small-animal model, in particular for large-series work, in a field previously limited to large animals such as dogs, pigs, and calves.
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