Abstract
Biological Renal clearance comprises multiple active and passive mechanisms, in turn leading to the formation of urine. In this article, a brief review of passive filtration in glomerular capillaries, active tubular secretion, and reabsorption is discussed. Factors affecting renal clearance have also been brought into the discussion, encompassing drug physicochemical properties, drug concentration, the volume of distribution, protein binding, blood flow to kidneys, biological factors, and drug interactions. Further, the necessity of dose adjustment in patients suffering renal impairment has been highlighted.
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