Abstract
Objective To constitute a crowd of multiple familial type 2 diabetes mellitus(T2DM) and to observe the effects of several risk factors of hypertension, lipid metabolic disorder, obesity and insulin resist. Methods According to American Diabetes Association criteria of diabetes, pedigrees with two or over two T2DM patients were chosen and all people were diagnosed by OGTT.Eight hundred and sixty–five persons from 182 pedigrees with two or more T2DM patients were analyzed after the type 1 diabetes mellitus, maturity onset diabetes of the young(MODY) and mitochondrial gene mutation pedigrees were excluded.The survey includes tests of blood glucose, insulin, C–peptide, lipids, etc. Results The prevalence of T2DM and impared glucose regulation impaired glucose regulation(IGR) was 59.88%, the prevalence of T2DM was 45.43%, including 94 T2DM and 102 IGR newly discovered, the prevalence of T2DM and IGR in the diabetes family was significant higher than those in the common populations. The systolic pressure, diastolic pressure blood lipid, BMI, HOMA–IR in diabetic group were obviously higher than those in IGR group or normal group. Conclusion There is significant familial aggregation in T2DM.The history of hypertension and hyperlipidemia and obesity are the risk factors of T2DM or IGR patients.Insulin resistance exists before the attack of diabetes mellitus. Key words: Diabetes mellitus, type 2; Pedigree; Population
Published Version
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