Abstract
Abstract: An improved strategy for the synthesis of terbinafine has been developed through the crosscoupling of (E)-aminovinyl chloride with tert-butyl acetylene using 1 mol% of 5% Pd/C as a recyclable heterogeneous catalyst under mild conditions. This is the first report on the Pd/C catalyzed Sonogashira coupling to produce the 99.9% pure terbinafine under mild conditions.
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