Abstract

目的 研究聚四氢呋喃聚乳酸共聚物(C4)对眼组织的毒性.方法将聚四氢呋喃聚乳酸共聚物分别置入兔眼玻璃体腔和前房内,定期进行临床观察和视网膜电图检查,6个月后摘除眼球行病理观察.结果聚四氢呋喃聚乳酸共聚物在兔眼玻璃体腔内(168.3±12.6)d完全降解,在前房内(136.5±9.6)d完全降解,视网膜电图正常,眼组织病理观察无异常,兔眼压于手术后第3 d及第120 d左右两次出现升高.聚合物直接接触角膜内皮1.5个月后内皮细胞消失.结论聚四氢呋喃聚乳酸共聚物对视网膜、晶状体无明显毒性,但不能直接接触角膜内皮。

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