Abstract
Pediatric hypertension is recognized as an emerging global health concern. While new guidelines are developed for facilitating clinical management, the reasons for the prevalence of hypertension in children remain unknown. We hypothesized that, similar to the known link between gut microbiota and adult hypertensives, alterations in gut microbiota that occur very early in childhood are also associated with an increased prevalence of pediatric hypertension. To test this hypothesis, we administered amoxicillin, the most commonly prescribed antibiotic to pediatric patients, to clear gut microbiota of just‐weaned, genetically hypertensive Dahl Salt‐Sensitive (S) rats. Amoxicillin treated rats had decreased BP compared to controls. This lowering effect on blood pressure persisted even after the antibiotics were discontinued. Results will be presented on the specific alterations in gut microbiota in response to amoxicillin treatment. Albeit in an experimental model, our results demonstrate the significant role of gut microbiota in the early development of hypertension and indicate that clearing dysbiotic gut microbiota early in childhood may have long‐term benefits for hypertension‐prone individuals.Support or Funding InformationFunding for this work to BJ from the NHLBI/NIH (HL143082) is gratefully acknowledged.This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.
Published Version
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