Abstract

Based on benzylthioctane-2-ol, heterocyclic amines (piperidine, morpholine, hexamethyleneimine), and formaldehyde, new Mannich bases were synthesized. The reaction was carried out at a temperature of 45–500C for 3–4 h. in an equimolar ratio of starting compounds. The yield of target products was 70–74%. The physicochemical data of the synthesized compounds were determined. The composition and structure of the target products were confirmed by elemental analysis, IR and 1H NMR spectroscopy. Their influence on the vital activity of sulfate-reducing bacteria of the Desulfovibrio desulfiricans type at three con¬centrations (25, 50, 100 mg/l) was studied. The obtained compounds showed high bactericidal pro¬perties, since 1% solutions of these compounds in isopropyl alcohol at a concentration of 100 mg/l showed a 100% bactericidal effect. Given that the aminomethoxy derivatives of 1-benzylthiooctane affect bacteria at very low concentrations, they can be proposed as effective inhibitors of sulfate reducing bacteria (SRB).

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