Abstract
Mesoporous silica KIT-6, has been prepared through the sol-gel method followed by a chemical modification using 3-aminopropyl triethoxysilane (APTS) to obtain KIT-6-NH2 as a drug delivery carrier. The mesostructure properties was fully characterized by transmission electron microscope (TEM), N2 sorption isotherm, Fourier transform infrared (FT-IR), low-angel X-ray diffraction (XRD) and small-angel x-ray scattering (SAXS). Loading of ketoprofen (KP) and 5-flurouracil (5-FU) drugs as models into KIT-6 and KIT-6-NH2 was studied using quartz crystal microbalance (QCM) and UV–visible spectroscopy. The loading uptake and release behaviors of KP and 5-FU were highly dependent on the textural properties of KIT-6 and KIT-6-NH2. The release of drugs was carefully studied in simulated gastric fluid (pH 2) and in simulated intestinal fluid (pH 7.4). First order, Higuchi, Hixson–Crowell and Korsmeyer–Peppas release kinetic models were applied to the experimental data and the release was found to obey a first-order rate kinetic.
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