Abstract
To investigate the association between ambient coarse particulate matter (PM2.5-10) pollution and risk of acute schizophrenia episodes. A time-stratified case-crossover study with a two-stage analytical approach was conducted to investigate the association between ambient PM2.5-10 pollution and schizophrenia admissions (an indicator for acute schizophrenia episodes) across 259 Chinese cities of prefecture-level or above during 2013-2017. A conditional logistic regression model was constructed to estimate city-specific changes in hospital admissions for schizophrenia associated with per interquartile range (IQR) increase in ambient PM2.5-10, and the overall associations were obtained by pooling the city-specific associations using the random-effects model. A total of 817,296 schizophrenia admissions were included in the analysis. Per IQR increase (28.43μg/m3) in PM2.5-10 at lag01 was associated with an increase of 1.66% (95% CI: 0.68%, 2.65%) in schizophrenia admissions. Compared to concentrations <30μg/m3, PM2.5-10 concentrations of 30-49μg/m3 and ≥50μg/m3 were associated with increases of 2.25% (95% CI: 0.73%%, 3.79%) and 4.03% (95% CI: 1.92%, 6.18%) in schizophrenia admissions, respectively. City-level urbanization has the potential to attenuate the association between ambient PM2.5-10 and schizophrenia admissions (P=0.0002). Our study provides novel evidence for the acute adverse effects of ambient PM2.5-10 on schizophrenia and calls for special attention on the control of high PM2.5-10 pollution in disease prevention.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call