Abstract
The quality improvement of medical care requires the developing of clinical laboratory patient support. To achieve the effective results need a searching, developing and applying in practice new, with improved properties, methods for estimation analytes, including common ones, such as α-amylase activity. This article presents a review of the main materials published over the past few decades. It includes a description of the structure of α-amylase and its main isoenzymes; its role in human physiology and pathology; diagnostic significance of the α-amylase isoenzymes activity determination in clinical laboratory diagnostics. The principles of the most common methods of α-amylase activity determination are presented, and their important characteristics are compared. The method based on the substrate GalG2CNP using has the best analytical characteristics for the developing reagent kits for measuring the total α-amylase and its pancreatic isoenzyme activities, which can be used in clinical diagnostic laboratories.
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