All-natural 5-MeO-DMT sigma receptor 1 agonist and its therapeutic impact in mental and neurodegener-ative diseases through mitochondrial activation

Abstract

The sigma-1 receptor S1R is a chaperone that resides mainly at the mitochondrion-associated endoplasmic reticulum ER membrane MAM, it is considered a “pluripotent modulator” in living systems, plays a critical role in maintaining neuronal homeostasis and acts as a dynamic pluripotent modulator in living systems. Given its specific localization at the MAM, S1R plays a major role regulating mitochondrial function, it is a therapeutic target in mental and neurodegenerative diseases including Alzheimer’s disease, Parkinson’s disease. N,N Dimethyl Tryptamine DMT is the S1R endogen agonists and we review the role of all-natural 5-methoxi-N,N-dimethyltryptamine 5-MeO-DMT S1R agonist that produces high levels of ego dissolution or oceanic boundlessness higher ratings of satisfaction with life and lower ratings of depression and stress. In vitro the 5-Meo-DMT shows strong modulation of synaptic and cellular plasticity in neurons. 5-MeO-DMT neuropharmacological S1R agonist is implicated in cellular bioenergetics activation, antiapoptotic and mitochondrial regulation of epigenetic landscape in neurons. S1R has been considered as a controller of cell survival and differentiation in neurons. The pharmacological benefits of all-natural 5-MeO-DMT are currently under research. This review compendia results, highlighting the key molecular mechanisms of S1Rs on mitochondrial functions and epigenetic modifications involved in the health and sickness phenotype development, and describe the possible pharmacological use of all-natural 5-MeO-DMT to “rescue” patients from sickness phenotype through mitochondrial activation. We focus on all-natural 5-MeO-DMT its clinical therapeutic implications benefit long-term effects on mental health and well-being of the patient possibly reprogramming and remodeling the epigenome, particularly in mental and neurodegenerative diseases.