Abstract
Many antioxidant compounds, flavonoids, and saponins are contained in starfruit leaves (Averrhoa carambola). The purpose of this study was to determine the antidiabetic activity of star fruit extract in mice. This study used a completely randomized design (CRD) with 6 treatments, namely P1 (aquadest without alloxan) as a negative control, P2 (aquadest with alloxan) as a positive control, P3 (metformin 500 mg / kgBB), P4 (alloxan + ethanol extract of star fruit leaves. 100 mg / kgBB), P5 (alloxan + ethanol extract of star fruit leaves 150 mg / kgBB), P6 (alloxan + ethanol extract of star fruit leaves 200 mg / kgBB). The starfruit leaf extract was made using the maceration method. In order for experimental animals to become diabetic, alloxan is used at a dose of 120 mg / kgBW which is injected intramuscularly into the thigh muscles. After the experimental animals were diabetic, We were given ethanol extract of starfruit leaves according to the experimental design, starting from day 7th to day 21st. Blood glucose levels are measured with a glucometer every week. The results showed that the best decrease in blood glucose levels occurred in the first week and the second week. In the first week, the metformin treatment was able to reduce blood glucose by 88.4%, while the ethanol extract treatment of star fruit leaves at a dose of 200 mg / kg BW was able to reduce blood glucose levels by 60%. The ethanol extract of star fruit leaves has antidiabetic activity. 
 Keywords: mice, diabetes mellitus, blood glucose, starfruit leaves.
Highlights
The results showed that the best decrease in blood glucose levels occurred in the first week and the second week
Jurnal Ilmu Farmasi dan Farmasi Klinik UniversitasPengaruh pemberian ekstrak teh hijau (Camellia sinensis l.) terhadap penurunan kadar kolesterol total tikus wistar (Rattus norvegicus) diabetes induksi aloksan
Summary
Daun belimbing besi yang sudah dikeringanginkan, ditumbuk/diblender menjadi tepung dan diekstrak menggunakan metode maserasi sesuai dengan yang dilakukan Dipa dkk. (2015). Daun belimbing besi yang sudah dikeringanginkan, ditumbuk/diblender menjadi tepung dan diekstrak menggunakan metode maserasi sesuai dengan yang dilakukan Dipa dkk. Tepung daun belimbing besi dimaserasi dengan ethanol 96% selama 3 hari, kemudian disaring. Filtrat kemudian dievaporasi dengan rotary evaporator pada suhu 40o C sampai semua etanol menguap dan menjadi crude extract (ekstrak kental). Hewan coba mencit diaklimasikan terlebih dahulu di dalam kandang percobaan selama 7 hari. Untuk membuat hewan coba menjadi diabetes dilakukan induksi mengggunakan aloksan dengan dosis 120 mg/kgBB yang disuntikkan secara intramuscular pada otot paha. Setelah kadar glukosa mencit yang diinduksi aloksan meningkat, selanjutnya mencit diberikan perlakuan ekstrak etanol daun belimbing besi secara oral sesuai rancangan percobaan dengan metode gavage/cekok dengan menggunakan sonde. Kadar glukosa darah diukur setiap minggu dengan menggunakan glucometer merk Easy Touch GCU.
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