Abstract
Background Age-associated disruptions in brain barrier systems (including choroid plexus) lead to multiple problems for CSF turnover and brain interstitial fluid composition. Age is a great risk factor for Alzheimer's disease (AD). We have presented evidence that beta-amyloid (Aβ) retention in AD is linked to decreased CSF turnover and reduced Aβ transport out of human brain. It is also known that CSF formation is reduced in aged rats (Preston et al.).
Highlights
Age-associated disruptions in brain barrier systems lead to multiple problems for CSF turnover and brain interstitial fluid composition
We have presented evidence that beta-amyloid (Aβ) retention in Alzheimer's disease (AD) is linked to decreased CSF turnover and reduced Aβ transport out of human brain
It is known that CSF formation is reduced in aged rats (Preston et al.)
Summary
Age-associated disruptions in brain barrier systems (including choroid plexus) lead to multiple problems for CSF turnover and brain interstitial fluid composition. Age is a great risk factor for Alzheimer's disease (AD). We have presented evidence that beta-amyloid (Aβ) retention in AD is linked to decreased CSF turnover and reduced Aβ transport out of human brain. It is known that CSF formation is reduced in aged rats (Preston et al.)
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