Abstract
The possible existence of correlations between bone mineral content (BMC), age and serum levels of steroid hormones was investigated. It was found that dehydroepiandrosterone sulphate (DHEA-S), oestradiol (E 2) and delta-4-androstenedione (A) were correlated with BMC, whereas oestrone (E 1) and testosterone (T) were not. Partial correlations after adjustment for age were significant ( P < 0.05) only between E 2 and DHEA-S and BMC at the L2–L4 lumbar site (BMC-1) and between DHEA-S ( P < 0.01) and BMC at the midradius site (BMC-r). Stepwise multiple regression analysis showed that, apart from age, E 2 was the only factor to fit ( P < 0.05) into the mathematical model with BMC-1 as the dependent variable, while DHEA-S was the only factor to fit ( P < 0.01) with BMC-r as the dependent variable. These data suggest that different hormonal influences are related to BMC at different sites, namely E 2 to lumbar trabecular bone (L2-L4) and DHEA-S to cortical bone (midradius).
Published Version
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