Abstract
Objective To investigate the morbidity of perinatal and maternal outcomes in singleton and twin pregnancies complicated by preeclampsia. Methods Published studies about pregnant outcomes in singleton and twin pregnancy complicated by preeclampsia were searched and screened in PubMed, Web of Science, SinoMed, Chinese Biological Medicine (CNKI), databases of Wanfang and VIP database of Chinese journal. Retrieval time from January 2000 to December 2017. The RevMan 5.3 and Stata 12.0 software were used for meta-analysis. The correlation between twin pregnancy complicated with preeclampsia and adverse pregnancy outcomes were analyze by Pooled odds ratio (OR) with 95% confidence interval (CI). Results There were 10 retrospective cohort studies, including 692 twin pregnancies complicated with preeclampsia and 3101 singleton pregnancies complicated with preeclampsia. Compared with the singleton pregnancies complicated with preeclampsia, adverse pregnant outcomes of twin pregnancies complicated with preeclampsia were increased, such as placental abruption (OR=2.16, 95%CI: 1.40-3.36), postpartum hemorrhage (OR=2.90, 95%CI: 2.03-4.15), heart failure (OR=3.73, 95%CI: 2.10-6.63), pulmonary edema (OR=2.76, 95%CI: 1.04-7.27), cesarean delivery (OR=2.27, 95%CI: 1.58-3.26), premature rupture of membrane (OR=2.99, 95%CI: 1.64-5.47), preterm delivery (OR=6.24, 95%CI: 4.16-9.38), the rates of newborn admitted to intensive care unit (OR=2.33, 95%CI: 1.66-3.26). Conclusion Compared to the singleton pregnancies complicated with preeclampsia, twin pregnancies complicated with preeclampsia increased the morbidity of placental abruption, postpartum hemorrhage, heart failure, pulmonary edema, cesarean delivery, premature rupture of membrane, preterm and the rates of newborn admitted to intensive care unit. Key words: Twin pregnancy; Pre-eclampsia; Pregnancy outcome; Meta-analysis
Published Version
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