Abstract
Abstract Background Data on adenovirus (AdV) infections in solid organ transplant recipients (SOTr) are scarce. The aims of this study were to examine the epidemiology and outcomes of AdV-disease in SOTr, and to assess the clinical utility of AdV-surveillance in SOTr <13 years. Methods All SOTr transplanted at Rigshospitalet, 2010-2021 were included in the study. The center had a screening program for SOTr aged <13 years with monthly PCR for AdV in blood the first six months following transplantation. Data on AdV-tests were obtained from nationwide microbiology and pathology registries and clinical data were obtained from medical records. Results We included 2,009 SOTr of whom 82 were aged <13 years. The adherence to the AdV-screening program was median 50% (IQR 16.7-100). During the study period 1,330 blood samples from 382 SOTr (439 from 58 SOTr <13 years) were analyzed for AdV, of which ten (0.8%) from six SOTr <13 years tested positive, incidence rate in SOTr <13 years 1.6/100 person-years (95% CI: 0.7-3.6). Five of the six were tested as part of the screening program. Three remained asymptomatic, while three had symptoms attributable to co-infections. None of the patients received antiviral treatment for AdV. One adult lung transplant recipient with AdV detected in BAL had acute exacerbation of chronic graft rejection. Conclusion We found a low incidence of AdV disease. SOTr <13 years diagnosed with AdV-viremia as part of screening remained asymptomatic or had symptoms attributable to co-infections. Our findings do not support routine surveillance for AdV in SOTr.
Published Version
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