ACYP2 polymorphisms are associated with the risk of liver cancer in a Han Chinese population.

Zhong Chen,Mengdan Yan,Jing Li,Tianbo Jin,Zhenxiong Xu,Junnv Xu,Yu Sun,Haifeng Lin,Jingjie Li

doi:10.18632/oncotarget.18574

Abstract

We explored the association between single nucleotide polymorphisms (SNPs) in ACYP2 and liver cancer risk. Thirteen SNPs were genotyped in 473 cases and 564 controls. Genetic model, linkage disequilibrium, and haplotype analyses were performed to evaluate the association between ACPY2 SNPs and liver cancer risk. We found that rs6713088 (G allele: odds ratio [OR] = 1.27, 95% confidence interval [CI]: 1.07−1.52, P = 0.007; GG vs. CC: OR = 1.49, 95% CI: 1.02−2.1, P = 0.038), rs843711 (T allele: OR = 1.29, 95% CI: 1.09−1.54, P = 0.004; TT vs. CC: OR = 1.62, 95% CI: 1.13−2.31, P = 0.008), rs843706 (A allele: OR = 1.30, 95% CI: 1.09−1.55, P = 0.003; AA vs. CC: OR = 1.62, 95% CI: 1.13−2.31, P = 0.008), and rs843645 (GG vs. AG: OR = 1.40, 95% CI: 1.07−1.82, P = 0.014) were associated with an increased risk of liver cancer. In contrast, rs1682111 (A allele: OR = 0.77, 95% CI: 0.640−0.94, P = 0.007; AT vs. TT: OR = 0.69, 95% CI: 0.53−0.91, P = 0.007), rs843720 (additive model: OR = 0.82, 95% CI: 0.68−1.00, P = 0.049), ATATCGCC and CG haplotypes (OR = 0.76, 95% CI: 0.62−0.92, P = 0.006; OR = 0.78, 95% CI: 0.65−0.93, P = 0.006, respectively) were significantly decreased liver cancer risk. Our results confirmed that rs6713088, rs843645, rs843711 and rs843706 were significantly increased liver cancer risk, but rs1682111, rs843720 and haplotypes (ATATCGCC and CG) were significantly decreased liver cancer risk in a Han Chinese population.

Highlights

Liver cancer is the second leading cause of cancerrelated death among men worldwide
The G allele of rs6713088, T allele of rs843711, and A allele of rs843706 were associated with a 1.27-fold, 1.29-fold, and 1.30-fold increased risk of liver cancer, respectively
No significant association between SNPs in Acylphosphatase 2 (ACYP2) and liver cancer risk was observed after Bonferroni correction

Summary

Introduction

Liver cancer is the second leading cause of cancerrelated death among men worldwide. There were an estimated 782,500 new liver cancer cases and 745,500 liver cancer-related deaths in 2012 worldwide. China alone accounted for approximately 50% of the total number of cases and deaths [1]. Liver cancer is a complex and multifactorial disease regulated by both genetic and environmental factors. Epidemiological studies have shown that the major environmental risk factors for liver cancer include chronic Hepatitis B virus (HBV). Not all individuals with exposure to these risk factors develop liver cancer. Hepatocellular carcinoma (HCC) accounts for between 70% and 85% of primary liver cancers. Some Genome-wide association studies (GWAS) have identified several loci associated with the risk of HCC, such as SNPs in the gene KIF1B, MICA, HLA-DQA/DQB, and GRIK1, respectively [4,5,6]

Methods

Results

Conclusion