MiRNA155HG polymorphisms influenced the risk of liver cancer among the Han Chinese population

Xu Chao,Yanni Chen,Hong Li,Yuewen Wang,Xiaoping Wang,Haiyu Shen,Hailong Shi,Qing Zha,Xuesong Feng,Lanlan Wang

doi:10.1186/s12881-020-01064-4

Abstract

BackgroundLiver cancer is one of the most common cancers in the world. The primary aim of this research was to discover the correlation between single nucleotide polymorphisms (SNPs) of the MIR155HG and liver cancer risk.MethodsThe selected SNPs in MIR155HG were genotyped utilizing the Agena MassARRAY platform. We evaluated the correlation between MIR155HG polymorphisms and Liver cancer by genetic model analysis, stratification analysis and haplotype analysis. Relative risk of Liver cancer was shown based on odds ratios (ORs) and 95% confidence intervals (95% CIs).ResultsOur results uncovered that rs12482371 and rs1893650 in the MIR155HG were associated with protection against Liver cancer. And the rs928883 was related to increase risk of Liver cancer. Furthermore, apart from rs77218221, other selected SNPs formed two LD blocks, and haplotype “GATAG” in block 2 elevated individual liver cancer risk.ConclusionsMIR155HG gene polymorphism may be correlated to Liver cancer susceptibility in Han Chinese population, particularly in males and aged ≤55 years.

Highlights

Liver cancer is one of the most common cancers in the world
We evaluated the risk of gene polymorphism in the allele model by chisquared test, and found that there were no associations between the single nucleotide polymorphisms (SNPs) and the risk of Liver cancer with all p > 0.05
Our results found that rs12482371 in MIR155HG was associated with a 0.56fold decrease in risk for Liver cancer under genotype model and a 0.55-fold decreased in risk for Liver cancer under recessive model

Summary

Introduction

Liver cancer is one of the most common cancers in the world. The primary aim of this research was to discover the correlation between single nucleotide polymorphisms (SNPs) of the MIR155HG and liver cancer risk. We evaluated the correlation between MIR155HG polymorphisms and Liver cancer by genetic model analysis, stratification analysis and haplotype analysis. Liver cancer is a common malignancy and the second leading cause of cancer death worldwide [1], accounting for 466,100 new patients and 422,100 deaths per year in China [2]. The major type of Liver cancer (70-80%) is hepatocellular carcinoma (HCC), followed by intrahepatic cholangio carcinoma [3]. Among all cancers in China, liver cancer had poorest survival with a 5year relative survival rate of only 10.1% [4]. Zhang H et al identified that internal polymorphism locus rs17401966 in KIF1B gene was highly correlated with HBV- associated HCC [15]

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Results