Abstract
Numerous evidence has revealed that single-nucleotide polymorphisms (SNPs) are associated with liver cancer risk. To assess whether the MIR17HG polymorphisms are associated with the liver cancer risk in the Chinese Han population, we performed a case–control (432 liver cancer patients and 430 healthy controls) study. Genotyping of four variants of MIR17HG was performed with the Agena MassARRAY platform. We used χ2 test to compare the distribution of SNPs allele and genotypes frequencies of cases and controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by logistic regression analysis to evaluate the association under genetic models. The results indicated that the rs7318578 was significantly associated with increased the risk of liver cancer in the allele (OR = 1.45, 95% CI: 1.18–1.77, P=3.04E-04), recessive (OR = 3.69, 95% CI: 2.45–5.56, P=4.52E-10) and additive model (OR = 1.35, 95% CI: 1.13–1.62, P=0.001). Moreover, we found that individuals with the genotype CC of rs7318578 presented with an increased risk of liver cancer (OR = 3.03, 95% CI: 1.98–4.65, P=3.83E-07); however, the CA genotype of rs7318578 significantly decreased the risk of liver cancer (OR = 0.61, 95% CI: 0.45–0.83, P=0.001, compared with those with the AA genotype. Our findings indicated that MIR17HG polymorphism (rs7318578) contributes to liver cancer susceptibility to the Chinese Han population. Further studies with larger samples are required to confirm the results, as well as functional studies to determine the role of this SNP in miRNA expression or molecular pathways.
Highlights
Liver cancer is predicted to be the sixth most commonly diagnosed cancer and the fourth leading cause of cancer death worldwide in 2018, with about 841,000 new cases and 782,000 deaths annually [1]
Numerous evidences have revealed that single-nucleotide polymorphisms (SNPs) are associated with liver cancer risk [5,6,7,8]
We investigated the association between miRNA 17-92 cluster host gene (MIR17HG) polymorphisms and liver cancer risk in the Chinese Han population
Summary
Liver cancer is predicted to be the sixth most commonly diagnosed cancer and the fourth leading cause of cancer death worldwide in 2018, with about 841,000 new cases and 782,000 deaths annually [1]. Liver cancer is commonly diagnosed and identified as leading causes of cancer death in China, with an estimated about 392,868 newly liver cancer cases and 368,960 death in 2018 [2]. The carcinogenesis of liver cancer is a complex and multistep process regulated by various risk factors. Epidemiological studies indicated that the major environmental risk factors of liver cancer include chronic infections of hepatitis B virus (HBV) and hepatitis C virus, exposure to aflatoxin, alcohol consumption and cigarette smoking, and diabetes [3,4]. Numerous evidences have revealed that single-nucleotide polymorphisms (SNPs) are associated with liver cancer risk [5,6,7,8]
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