Abstract
An experimental model of chronic oral candidiasis, which adequately reproduces the recurrence of the disease and can be used to study the major pathogenic mechanisms of the disease and determine the effectiveness of antifungal drugs. Under the experimental conditions studied pathological changes that occur at different stages of infection in the mouth, the digestive system, liver, and spleen of experimental animals. The dynamics of the immune response during relapse of experimental oral candidiasis and stages of secondary imunodefficiency postinfection.
Highlights
Chronic lesions of oral mucosa are one of the topical problems of modern pediatric dentistry and gastroenterology due to its prevalence, severe clinical deployments and risks of recurrency
The specific weight of candidial lesions of oral mucosa has increased significantly due to the augmentation of a number of severe and atypical clinical forms, which are resistant to traditional therapy, high risk of complications and infection generalization
On the 7th and 21th days of the disease, infecting was micologically confirmed in 82.1% and 66.1% of the rats, which survived with sufficiently high semination by Candida species yeasts (2.00-0.21 lgCFU/ml; 2.50-0.14 lgCFU/ml), which is indicative of chronic candidiasis of oral mucosa
Summary
Chronic lesions of oral mucosa are one of the topical problems of modern pediatric dentistry and gastroenterology due to its prevalence, severe clinical deployments and risks of recurrency.
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