Abstract
Opiates and cholinergics are purported to have interacting antinociceptive mechanisms. The aim of the present study was to evaluate the opiate/cholinergic interaction within the medial thalamic parafascicular nucleus (Pf) of rats. We previously demonstrated that administration of the cholinergic agonist carbachol or the μ-opioid agonist morphine into Pf suppressed the production of vocalization afterdischarges (VADs) of the rat, a validated model of pain affect. In the present study, the antinoceptive effects of Pf-morphine were challenged by the local administration of the muscarinic antagonist atropine.
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