Abstract
Abstract The selective functionalization of inactive CH bonds is a subject of continuous exploration by synthetic organic chemists. Recent approaches relying on hydrogen atom transfer (HAT) processes have led to a tremendous revival in this field, due to the ability to activate inert CH bonds becoming more easily under mild conditions. HAT is applicable to a wider range of applications, possessing a higher tolerance of functional groups. Many synthetic methods based on HAT have been widely reported in the last few years. Recently, developments in mild methods for generating various central radicals have enabled them to be utilized in HAT processes, which in turn led to the development of remote C(sp 3 )H functionalization reactions for alcohols, amines, amides, and related compounds. This article mainly covers recent advances in 1, n ‐HAT ( n = 4–8) methods involving photocatalytic, electrocatalytic, and metal‐catalytic approaches to CH functionalization reactions.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
