Activation of CH Bonds Through 1, n ‐HAT ( n = 4–8) Pathway

Abstract

Abstract The selective functionalization of inactive CH bonds is a subject of continuous exploration by synthetic organic chemists. Recent approaches relying on hydrogen atom transfer (HAT) processes have led to a tremendous revival in this field, due to the ability to activate inert CH bonds becoming more easily under mild conditions. HAT is applicable to a wider range of applications, possessing a higher tolerance of functional groups. Many synthetic methods based on HAT have been widely reported in the last few years. Recently, developments in mild methods for generating various central radicals have enabled them to be utilized in HAT processes, which in turn led to the development of remote C(sp 3 )H functionalization reactions for alcohols, amines, amides, and related compounds. This article mainly covers recent advances in 1, n ‐HAT ( n = 4–8) methods involving photocatalytic, electrocatalytic, and metal‐catalytic approaches to CH functionalization reactions.