Abstract
THE CONTEMPORARY literature is replete with reports of the action of adrenocorticotropic and corticoid hormones on various body tissues. The skin has not been exempt from such studies and clinical observations. However, much of the material in this field has been contradictory or inconclusive. Because of this, the following experiments were undertaken to determine if controlled evidence of a protective mechanism through the use of supplementary corticoid hormone in intact animals could be demonstrated against certain types of injury to the skin. Three rather distinctive and assayable methods of producing alteration in the skin were chosen: (1) ionizing radiation, (2) contact hypersensitivity reaction, and (3) podophyllin (podophyllum resin) damage. MATERIALS AND METHODS The cortisone acetate (11-dehydro-17-hydroxycorticosterone; Cortone 1 ) used was the commercial preparation and is hereafter referred to simply as cortisone. The injectible form contained 25 mg. per cubic centimeter of solution before further dilution. The ointment form was
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