Abstract
Objective Purpose of this study was to evaluate the accuracy of CT-guided percutaneous automated cutting needle biopsy (ACNB) of lung lesions and to determine its influencing factors in diagnosis of malignancy.Methods Clinical data of 352 patients undergone with ACNB was retrospectively analyzed for its accuracy in diagnosis of malignancy and its potential predictive variables, with unconditional logistic regression model.Results Mean length of percutaneous puncture for ACNB was (16.0 ± 2.0) min.Two hundred and forty-six of 352 patients were diagnosed as malignant, with sensitivity and specificity for diagnosis of malignancy of 92.7% and 100.0%, and positive and negative predictive values of 100.0% and 85.5%, respectively.Overall accuracy of its diagnosis of malignancy was 94.9%.Results of multivariate analysis showed that size of lung lesion equal to or smaller than 20 mm and those complicated with pulmonary atelectasis (with ORs of 4.198 and 2.210, respectively) associated with its negative positivity.Eighty (22.7%) cases presented pulmonary hemorrhage, 18 (5.1%) hemoptysis, 60 cases (17.0%) pneumothorax and two (0.6%) needed a chest tube for drainage after the procedure.One case had insistent pain for more than one month and one with pleural reaction caused by pulmonary cryptococcus infection.Conclusions CT-gnided ACNB was a feasible, safe and accurate method for diagnosing pulmonary lesions, pulmonary malignant lesions less than 20 mm in diameter and complicated with pulmonary maybe affect accuracy. Key words: Lung disease; Biopsy; Tomography; spiral computed
Published Version
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