Abstract
Objective To explore a quantitative scoring system based on PET/CT and high - resolution computed tomography (HRCT) characteristics for differentiating benign and malignant solitary pulmonary lesions. Methods A total of 112 patients with solitary pulmonary lesions detected by 18F-FDG PET/CT were enrolled and reviewed retrospectively. Of these cases, 44 were benign lesions and 68 were malignant. PET/CT and HRCT imaging features were recorded and evaluated. A quantitative scoring system was established. The best cut - off score was calculated by analysis of receiver operating characteristics (ROC) in differentiating benign and malignant lesions. Results The indicators of malignant solitary pulmonary lesions by PET/CT and HRCT included age≥60 years (2 points) , diameter of the lesion≥1 cm (2 points) , heterogeneous density (2 points) , clear boundary (1 point) , SUVmax ≥2.5 (2 points) , ΔSUVmax≥1.0 (2 points) , retention index (RI) ≥15% (2 points) , lobular sign (3 points) , spiculation sign (3 points) , pleural traction sign (3 points) , and vacuole sign (3 points) . A quantitative scoring system was established according to risk factors. Moreover, score 12 was the best cut - off by ROC analysis in differentiating benign and malignant lesions. The sensitivity and specificity rates were 92.6% and 81.8%, respectively. Conclusion The quantitative scoring system based on PET/CT and HRCT features exhibited a good capacity for differentiating malignant lesions from benign solitary pulmonary lesions. Key words: Solitary pulmonary lesions; Positron-emission tomography; Tomography, X-ray computed
Published Version
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