Abstract
Abstract We have previously developed a bacterial cancer therapy strategy using the genetically-engineered strain, Salmonella typhimurium A1-R (A1-R). A1-R has been shown to be effective against metastatic human prostate, breast, and pancreatic cancer cell lines as well as osteosarcoma, fibrosarcoma, and glioma cell lines in nude mouse models. In the current study, we have evaluated Traditional Chinese Medicine (TCM) (Huang Zi, Mai Men Dong, Mu Dan Pi, Sheng Di Huang) in combination with A1-R bacterial therapy in a syngeneic orthotropic model of 4T1 mouse breast cancer. TCM treatment improved the host's ability to clear bacteria from the liver and spleen and prevent body weight loss after bacterial infection. Fur discoloration and reduced activity was also observed in mice treated with A1-R only, but ameliorated when bacterial treatment was combined with TCM. The combination of TCM and A1-R enabled S. typhimurium to be safely administered at a dose of 1×107 CFU once a week i.v. for a long period of time in immunocompetent mice. Efficacy and survival were increased by combination treatment compared to monotherapy with A1-R (1 × 107CFU) . The results of the present study suggest that TCM potentiates A1-R cancer therapy. Citation Format: Yong Zhang, Nan Zhang, Shibing Su, Robert M. Hoffman, Ming Zhao. Traditional Chinese Medicine (TCM) enhances efficacy and reduces toxicity of tumor-targeting S. typhimurium A1-R in a syngeneic breast cancer metastatic mouse model. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3306. doi:10.1158/1538-7445.AM2013-3306
Published Version
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