Abstract 1943: Highly specific tumor-targeting near-infrared persistent luminescence nanomaterials (ZGO and LGGO) for lung cancer bioimaging

Abstract

Abstract Lung cancer cells grow in-situ usually results in metastasis and is frequently recurrent after therapy. Moreover, treatment of lung cancer using surgery or chemotherapy is difficult to determine that all tumor tissue has been removed. ZnGa2O4/La3GaGe5O16 (ZGO and LGGO) persistent luminescence nanomaterials (PLNs) which are based on the biological characteristics of metastatic or remaining lung cancer cells, to promote the clinical application of these nanomaterials for long-term specific tracking. A silica shell-assisted synthetic route for mono-disperse, near infrared-PLNs, will be developed and applied in the, in vitro cell model and in vivo mouse model. The Cr3+-doped PLNs can hold the emitted light longer than several hours. These NIR-PLNs will absorb the energy of UV or X-ray light first and retain fluorescence emission. Moreover, we will identify the specific aptamer, MAGE-A3, and modify the PLN’s design accordingly, to increase the ability of cancer targeting. These targeted molecules can track the metastatic cell with specific binding. The advancement of nanoscale techniques in lung cancer is an urgent need. Hence, this research will deliver a credible diagnostic strategy and a novel method for therapeutic administration. To evaluate the luminescent effect in vitro and in vivo of NIR-PLNs, repeated in vivo NIR persistent luminescence images of a mouse after intravenous injection (I.V.) and intratracheal injection (I.T.) of NIR-PLNs. After the NIR-PLNs is irradiated with UV light for 120 seconds in vitro, the particles are entering in the mouse by I.V. and I.T. It is seen that NIR persistent luminescence signal could be repeatedly observed over the mouse’s lung tumor tissue for more than 6 hours. Interestingly, no significant NIR luminescence signal can be observed in the other parts of the mice. The major task is, providing a potential strategy for diagnostic in lung cancer. The current diagnostic approach does not easily distinguish the metastatic and remaining tumor cells. Moreover, we anticipate that our designed nanoplatform or accessed procedure could be applied to other types of materials or cancers, leading NIR-PLNs nanomaterials to the exploration of gene-scale research. Citation Format: Ming-Hsien Chan, Ru-Shi Liu, Michael Hsiao. Highly specific tumor-targeting near-infrared persistent luminescence nanomaterials (ZGO and LGGO) for lung cancer bioimaging [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1943.