Abstract
An efficient, unified approach to chiral, protected β-hydroxy γ-amino and α-hydroxy β-amino acids derived from Boc-l-leucine has been accomplished on the basis of the oxazaborolidine-controlled, stereoselective reduction of 1-trialkylsilyl acetylenic ketones; stereoselectivity in the reduction step has shown strong dependence upon C(1) substitution.
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