Abstract
Reduction of ketones by a crude alcohol dehydrogenase from Geotrichum candidum with a reductant, 2-alkanol, affords the corresponding ( S)-alcohols of excellent ee in high yield. The substrate specificity of the biocatalyst is very wide: ketones including β-keto esters, aromatic and aliphatic ketones and trifluoromethyl ketones are reduced enantioselectively in >99% ee in almost all reductions. The stereochemical course observed in the reduction of methyl ketones is different from that of trifluoromethyl ketones in spite of high enantioselectivity of the reaction.
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