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Abstract
The stereoselectivity of reduction of selected ketones by a variety of Complex Reducing Agents (resulting from the Aggregative Activation of NaH and symbolized MCRA's) has been investigated. The stereochemistry of reduction is shown to be dependent on the nature of the metal. Steric hindrance plays an important role and the apparent size of the reagents follows the trend MnCRA's>ZnCRA's, CdCRA's>NiCRA's, CoCRAs. On the other hand NiCRA's and CoCRA's have been found as very strong isomerizing reagents. Insertion of the metal species into the C-O bond with formation of metallacycles appears as one of the possible mechanisms intervening during the reduction of ketones by MCRA's
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