Abstract
Background: Eclampsia is a hypertensive disorder related to pregnancy, in which there is occurrence of one or more generalized convulsions and or coma, in the absence of other neurologic conditions. It is a common obstetric emergency. Eclampsia is associated with elevated maternal and fetal morbidity and mortality. Objectives : To compare the efficacy of low dose magnesium sulphate (Dhaka) regime with Pritchard regime in Eclampsia. Material and Methods : A prospective randomized study of fifty eclampsia cases, treated with magnesium sulphate (25 each from low dose magnesium sulphate (Dhaka) regime and Pritchard regime) was carried out for one year i.e. January 2010 to December 2010 at Pravara Rural Hospital, Loni. Results were analysed using Statistical Package of Social Sciences (SPSS) 13.0. Results: In the present study, convulsions were controlled in 88% of eclampsia cases with low dose magnesium sulphate (Dhaka) regime. Two cases i.e. 8% had single episode of recurrence of convulsion, which was controlled by giving additional 2 grams of 20% magnesium sulphate intravenous single dose. Perinatal mortality in low dose magnesium sulphate (Dhaka) regime was lesser (24%) than Pritchard regime (32%). Conclusion: Low dose magnesium sulphate (Dhaka) regime was equally effective as Pritchard regime in control of eclamptic convulsions. There was no magnesium related toxicity with low dose magnesium sulphate (Dhaka) regime. Maternal and perinatal outcome was better in low dose magnesium sulphate (Dhaka) regime as compared to Pritchard regime. Key words : Low dose magnesium sulphate (Dhaka) regime, Pritchard regime, Eclampsia, Maternal and foetal outcome
Highlights
Eclampsia is a hypertensive disorder related to pregnancy, in which there is occurrence of one or more generalized convulsions and or coma in the setting of preeclampsia and in the absence of other neurologic conditions[1]
It was observed from table 1 that, about 40% women in low dose magnesium sulphate (Dhaka) regime and 52% women in Pritchard regime was in the age group of 21-25 years
In Pritchard regime mean serum magnesium levels 15 minutes after the loading dose was 6.1 mEq/L and 12 hours after loading dose was 5.2 mEq/L. It was seen from table 3, that convulsions were controlled in 88% of cases with loading dose of low dose magnesium sulphate (Dhaka) regime and 100% of cases with Pritchard regime
Summary
Eclampsia is a hypertensive disorder related to pregnancy, in which there is occurrence of one or more generalized convulsions and or coma in the setting of preeclampsia and in the absence of other neurologic conditions[1]. Eclampsia is a hypertensive disorder related to pregnancy, in which there is occurrence of one or more generalized convulsions and or coma, in the absence of other neurologic conditions Results: In the present study, convulsions were controlled in 88% of eclampsia cases with low dose magnesium sulphate (Dhaka) regime. Maternal and perinatal outcome was better in low dose magnesium sulphate (Dhaka) regime as compared to Pritchard regime
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