English

Abstract

OBJECTIVES: The aim of the study is to compare the Low dose magnesium sulphate regime Vs standard dose with regard to the efficacy, maternal outcome and fetal - neonatal outcome. MATERIALS & METHODS: The study was conducted at Govt. General Hospital Kakinada from June 2009 to September 2010. A Total of 100eclampsia patients were studied with50 cases in each group. In Low dose regime, a loading dose of 4gm Magnesium Sulphate (20ml of 20% solution) given slow IV over 20 minutes. This is compared to standard Pritchard regimen and a maintenance dose of 2gm deep IM 4 th hourly up to 24hrs after delivery/ last convulsion whichever is later. RESULTS: Low dose magnesium sulphate regimen is as effective as Pritchard standard regimen in controlling eclamptic convulsions. No increase in maternal morbidity, mortality and no increase in perinatal morbidity, mortality were noted in the study group. CONCLUSION: A lower dose of magnesium sulphate is suitable and equally effective in Indian women who on an average weigh much less than the western counterparts to control convulsions in eclampsia with no increase in maternal mortality & morbidity (or) perinatal mortality & morbidity with the added benefit of reducing the side effects. The results obtained with this low dose regime bring out the focus for the need to review the correct dose of magnesium sulphate in Eclampsia in Indian scenario.