A Study on the LH-specificity in Patients with Type-2 Diabetes Mellitus of North India

Abstract

Background: Diabetes mellitus is a group of metabolic diseases and has become epidemic worldwide. The present study was conducted to find the LH status of patients with diabetes mellitus with the anti-LH lectin Erythrina lithosperma . Methods: A confirmed 263 cases with type 2 diabetic mellitus and 251 controls were enrolled in the study. ABO typing was done by normal serological procedure. LH typing was done with appropriate procedure. ABO blood group and LH specificity were compared in diabetic and control groups. Results: Patients with diabetes mellitus had higher frequency (41.06%) in LH-negative type than controls (14.34%), showing highly significant differences (p<0.001) between them. Statistically significant differences (p<0.05-0.001) were noted in blood group B, AB and O between these two sets of population. Conclusion: It might be concluded from the findings of the present study that diabetic patients had significantly more LH negative type as compared to controls, because the erythrocyte membrane in diabetic patients were always in hyperglycemic environment and membrane receptors were saturated with glucose molecules, leaving less availability of receptors to bind with anti-LH lectin Erythrina lithosperma.