Abstract
The phytochemicals are endowed with antioxidant activities because of the presence of plentiful polyphenols and many other phytochemicals. However, some recent reports have suggested that phytochemicals from certain plant species exhibit DNA damaging properties mainly due to presence of alkaloids. In the present study, pBR322, Salmonella typhi DNA, insect DNA and human DNA were treated with hexanolic extract of Argemone mexicana and Thevesia peruviana leaves to assess their DNA damaging abilities. Another set of experiments was carried out using the methanolic extracts of Citrus lemon leaves to assess their DNA protecting abilities from damage of DNA by extracts of A. mexicana and T. peruviana at 150000 ppm for all DNAs used. The results indicated that the leaves extract of A. mexicanaand T. peruviana demonstrated significant DNA damaging potential at higher concentrations. In contrast, the extracts from C. limonat 15000 ppm showed maximum DNA protective properties for all DNAs used.
Highlights
DNA is a complex molecule that contains the information necessary to build and maintain an organism
The results from the present study have indicated that the A. mexicana and T. peruviana leaves extracts were able to cause significant DNA damage in vitro in a concentration dependent manner
The results of the present in vitro study indicated that the extracts of leaves of T. peruviana and A. mexicana were causing damage to DNA isolated from different living systems whereas C. limon was able to protect the DNA from damage in the concentration dependent manner
Summary
DNA is a complex molecule that contains the information necessary to build and maintain an organism.
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