Abstract
Background: Enuresis is one of the most common problems in children hampering daily lives and studies. Homoeopathy can be used in enuresis, however not much research has been done regarding this. This study was aimed to investigate whether homoeopathic medicines have effect in the treatment of patients with primary enuresis. 
 Method: It is a randomized, single blind placebo control study, conducted at the outpatient department of Bharati Vidyapeeth (deemed to be university) Homeopathic college and research Centre, Pune. Total 45 patients enrolled, out of which 5 were dropped out and 40 completed trials with follow-ups. Outcome assessment was checked according to Likert scale and intensity of symptoms were recorded. 
 Result: The final outcome was reduction in number of wet nights per week, decreased in no of wet nights per day, decreased in associated symptoms of enuresis along with behavioural change in patients with primary enuresis after 12 -14 weeks of outpatient care. Analysis was done using student paired “t” tests and one sample “t” test. A significant improvement was observed after treatment and patients showed symptomatic relief as well. Mean reduction in intensity of symptoms in experimental group is 23.80, in control group was 9.05 after completion of study. 
 Conclusion: Constitutional Homoeopathic medicines produced significant effect in improving primary enuresis. Further studies with larger sample size and control group can provide a greater resource for proving that constitutional homoeopathic medicines have an effect in treatment in primary enuresis.
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