Abstract
The magnetic hollow silica spheres (MHSS) with uniform cavity size and shell thickness were prepared by a simple and “green” method using functionalized SiO2 spheres as templates. Magnetic particles (Fe3O4) were deposited on the SiO2 surface by varying the molar ratio of [Fe2+]/[Fe3+] and the molar concentration of iron salts. The obtained magnetic hollow silica spheres exhibited a super-paramagnetic behavior at room temperature. Scanning electron microscopy (SEM), transmission electron microscopy (TEM), and X-ray powder scattering (XRD) were applied to characterize the MHSS. Besides, their unit cell parameters are calculated according to results indexing to XRD, the MHSS sample prepared at 0.10 M iron salts and 2:1 molar ratio of [Fe2+]/[Fe3+] has a largest cell angle (β) of unit cell. Due to large hollow cavity space and super-paramagnetic characteristics, the inner amino-functionalized MHSS could be labeled with radioisotope 99Tcm to study the MHSS’s magnetic targeting distribution in vivo. These results indicate that the MHSS has potential in the magnetic targeted drug delivery system which reduces the damage to normal cells and improves the therapeutic effect of cancer.
Highlights
IntroductionHollow magnetic silica spheres (MHSS) have received great attention in many fields including catalysts [1] [2], microwave absorbing material [3], drug carriers [4] [5] [6] and the immobility of biomolecules [7] [8] [9], due to their unique properties such as low toxicity, biocompatibility, high specific surface area and huge interior space, which
The peak at 2555 cm−1 is attributed to the stretching vibrations of S-H, the peaks at 698 cm−1 and 753 cm−1 are attributed to the stretching vibration of the monoreplacement in the phenyl ring group of samples, and the peak at 1035 cm−1 is attributed to the vibration of Si-O-Si
These findings indicate that the mercapto group is presented in Thiol-Functionalized Hollow Silica Spheres (THSS)
Summary
Hollow magnetic silica spheres (MHSS) have received great attention in many fields including catalysts [1] [2], microwave absorbing material [3], drug carriers [4] [5] [6] and the immobility of biomolecules [7] [8] [9], due to their unique properties such as low toxicity, biocompatibility, high specific surface area and huge interior space, which. Zhu et al prepared the rattle-like Fe3O4@SiO2 hollow mesoporous spheres using the carbon spheres absorbed with iron precursor as the templates [13]. One is that the inner and outer walls of the hollow microspheres are functionalized. Caruso’s group [17] demonstrated that a new concept for the immobilization of enzymes using inner functionalized hollow microspheres, which displayed improved enantioselectivity in a given reaction. Hollow mesoporous spheres were prepared by polyelectrolyte almost have semi-permeable, so the small-molecule solvent, vitamin B12, dye or ions can penetrate through which is conducive to small-molecule drug sustained release. We reported an efficient route to prepare MHSS using the sulfonated SiO2 spheres as the hard templates by a simple and “green” method using co-precipitation route. Thiol groups of the hollow silica spheres are oxidized as sulfonic acid groups by hydrogen peroxide, and silica/Fe3O4 hollow spheres are prepared
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